BCKDK and EIF3C

		BCKDK	EIF3C
Description		branched chain keto acid dehydrogenase kinase	eukaryotic translation initiation factor 3 subunit C
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Alpha-ketoglutarate Dehydrogenase Complex	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Ribosome Binding
	Biological Process	Protein Phosphorylation Cellular Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Phosphorylation Glucose Homeostasis Negative Regulation Of Pyruvate Dehydrogenase Activity	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Positive Regulation Of Translation Positive Regulation Of MRNA Binding
Pathways		Branched-chain amino acid catabolism	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs		Adenosine 5'-[Î³-thio]triphosphate
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Parkinson's disease ( 25064009)	Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574)
Interacting Genes		17 interacting genes: APP BCKDHB CDIPT EIF3C EPS8 FBXO7 FOXO1 GUCA1A LSM8 NR5A2 PCDHB9 QPRT SETD1A STAT3 TAOK2 TRAF4 ZNF267	17 interacting genes: AAGAB ALKBH4 BCKDK CALM1 EIF1AX EIF3E EIF3G EIF3J EIF3K HMOX2 MAPK6 NDUFA4L2 PFDN1 RPS6KA3 SMAD9 SNIP1 TACC3
Entrez ID		10295	8663
HPRD ID		12523	04889
Ensembl ID		ENSG00000103507	ENSG00000184110
Uniprot IDs		A0A024QZA9 O14874	A0A024QYU9 Q99613
PDB IDs			3J8B 3J8C
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?