CDKN1C and CDK4

Number of citations of the paper that reports this interaction (PubMedID 9106657)
345

Data Source:
HPRD (in vivo)

		CDKN1C	CDK4
Description		cyclin dependent kinase inhibitor 1C	cyclin dependent kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Bicellular Tight Junction Nuclear Membrane Perinuclear Region Of Cytoplasm Cyclin D2-CDK4 Complex
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein-containing Complex Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Protein-containing Complex Binding
	Biological Process	Cell Cycle Arrest Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cyclin-dependent Protein Kinase Activity	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Lens Development In Camera-type Eye Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Circadian Rhythm Positive Regulation Of Cell Proliferation Response To Toxic Substance Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Animal Organ Regeneration Cellular Response To Insulin Stimulus Response To Testosterone Regulation Of Multicellular Organism Growth Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Cell Cycle Positive Regulation Of Cell Size Regulation Of Insulin Receptor Signaling Pathway Regulation Of Lipid Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Lipid Catabolic Process Cell Division Response To Hyperoxia Adipose Tissue Development Negative Regulation Of Cell Cycle Arrest Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Ionomycin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Cyclin D associated events in G1	SCF(Skp2)-mediated degradation of p27/p21 Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional regulation by RUNX2 Meiotic recombination Transcriptional regulation of granulopoiesis Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Drugs			Purvalanol Alvocidib Palbociclib Ribociclib Abemaciclib
Diseases		Beckwith-Wiedemann syndrome Adrenal carcinoma	Glioma Malignant melanoma Cervical cancer
GWAS		Birth weight ( 31043758) Calcium levels ( 20705733)	Celiac disease or Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		10 interacting genes: AKT1 CCNE2 CDK4 FBXL12 LIMK1 MYOD1 NR4A2 PCNA RB1 SKP2	131 interacting genes: AKT1 ANKRD12 ANXA7 APLP1 APP ARAF ARID4A ARNT ATP5F1B BAG6 BCL11A BECN1 BIRC5 BMPR1B BRCA1 CAMK1 CAPNS1 CCND1 CCND2 CCND3 CCNE1 CD44 CDC37 CDC45 CDC6 CDC7 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 CNTN2 DAZAP2 DDAH2 DUSP9 EIF4EBP2 EPHA2 ERBB2 FGFR4 FOXM1 FZR1 GLIS2 GRM1 H1-0 H1-1 H1-3 HGF HIF1A HMGXB3 HOOK1 HSP90AA1 IFI27 IGF1R IL15RA KDELR2 LATS2 LNX2 LUC7L2 MAP2K3 MAP2K5 MAP3K5 MAPK14 MAPRE2 MARCKS MCM2 MDM4 MET MYC MYOD1 MZF1 NCOA2 NF2 NOL12 ORC3 OTX2 PDGFRA PGD PIAS1 PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS1 RAF1 RASSF1 RB1 RBL1 RBL2 RFC1 RFC4 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA SPOP STK11 STUB1 TEAD2 TERT TGFBR1 TK1 TP53 TRMT2A TSC1 TSPYL2 UBE3A UBTF UHRF2 USP17L2 VTA1 WDR33 YBX3 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655
Entrez ID		1028	1019
HPRD ID		02913	00447
Ensembl ID		ENSG00000129757	ENSG00000135446
Uniprot IDs		P49918	A0A024RBB6 P11802
PDB IDs			1LD2 2W96 2W99 2W9F 2W9Z 3G33 5FWK 5FWL 5FWM 5FWP
Enriched GO Terms of Interacting Partners?
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