FLOT1 and SORBS3

Number of citations of the paper that reports this interaction (PubMedID 11481476)
38

Data Source:
BioGRID (pull down)

		FLOT1	SORBS3
Description		flotillin 1	sorbin and SH3 domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Uropod Lysosomal Membrane Endosome Early Endosome Microtubule Organizing Center Plasma Membrane Caveola Cell-cell Junction Adherens Junction Focal Adhesion COP9 Signalosome External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Cortical Actin Cytoskeleton Cytoplasmic Vesicle Centriolar Satellite Sarcolemma Melanosome Cell-cell Contact Zone Membrane Raft Presynaptic Active Zone Extracellular Exosome Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	Membrane Raft Assembly Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Axonogenesis Extracellular Matrix Disassembly Positive Regulation Of Protein Binding Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Interferon-beta Production DsRNA Transport Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Endoplasmic Reticulum Stress Regulation Of Rho Protein Signal Transduction Plasma Membrane Raft Assembly Positive Regulation Of Endocytosis Positive Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Neurotransmitter Uptake Positive Regulation Of Cell Adhesion Molecule Production Protein Kinase C Signaling Cellular Response To Exogenous DsRNA Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Positive Regulation Of Cell Junction Assembly Protein Localization To Membrane Raft Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		Synaptic adhesion-like molecules	Smooth Muscle Contraction
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) General cognitive ability ( 29844566) Handedness (non-right-handed vs right-handed) ( 31504236) Schizophrenia ( 30285260) Sleep duration ( 25469926) Ulcerative colitis ( 20848476)	Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		18 interacting genes: APP ARG1 AURKB CAPN10 CBL FLOT2 FYN GOLM1 HGS INCENP NGB PSMD4 SHBG SORBS1 SORBS2 SORBS3 SRPK1 UBC	46 interacting genes: ABL1 ADAM15 ADAMTSL4 ARNT2 CBLB CPEB2 CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCK1 NCKIPSD NOTCH3 PAK2 PAK5 RBMX SAFB2 SAXO1 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2
Entrez ID		10211	10174
HPRD ID		06105	11535
Ensembl ID		ENSG00000137312	ENSG00000120896
Uniprot IDs		O75955 Q5ST80	O60504
PDB IDs			2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?
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