AASS and WASL

		AASS	WASL
Description		aminoadipate-semialdehyde synthase	WASP like actin nucleation promoting factor
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Intracellular Membrane-bounded Organelle	Cell Nucleus Cytosol Actin Filament Plasma Membrane Actin Cytoskeleton Lamellipodium Actin Cap Actin Cortical Patch Endocytic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity	Protein Binding GTPase Regulator Activity Actin Filament Binding
	Biological Process	Lysine Catabolic Process Lysine Biosynthetic Process Via Aminoadipic Acid L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Oxidation-reduction Process	Actin Cortical Patch Assembly Endocytosis Vesicle Budding From Membrane Actin Polymerization Or Depolymerization Regulation Of Cell Shape Response To Bacterium Vesicle Organization Actin Filament Polymerization Actin Filament-based Movement Vesicle Transport Along Actin Filament Regulation Of Protein Localization Cellular Protein-containing Complex Localization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Actin Nucleation Cell Division Positive Regulation Of Filopodium Assembly Spindle Localization Actin Cortical Patch Localization Dendritic Spine Morphogenesis Membrane Organization Protein-containing Complex Assembly Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Lymphocyte Migration Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Lysine catabolism	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation NOSTRIN mediated eNOS trafficking Nephrin family interactions EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		Glutamic Acid NADH Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate N-(5-Amino-5-Carboxypentyl)Glutamic Acid
Diseases		Hyperlysinemia
GWAS			Platelet count ( 22139419 27863252) Plateletcrit ( 27863252)
Interacting Genes		6 interacting genes: ARF5 CCR6 CHCHD3 FSCN3 PTPRZ1 WASL	51 interacting genes: AASS ABL1 ACTG1 ACTR2 ACTR3 APBB1 APP ARPC3 BIN1 CDC42 CORO7 CTTN DNMBP EGFR EVL FCHSD2 FNBP1 FNBP1L GRB2 HP HSP90AA1 HSP90AB1 IPO5 ITSN1 ITSN2 LCK NCK1 NCK2 NCKIPSD PACSIN1 PACSIN2 PACSIN3 PFN1 PRMT2 PRPF40A PSTPIP1 PTK6 RHOJ RHOQ RNF8 RPL7AP66 SDCBP SH3GL3 SNX9 SRC TRIP10 VASP VIPR1 WIPF1 WIPF2 ZNF395
Entrez ID		10157	8976
HPRD ID		05489	05448
Ensembl ID		ENSG00000008311	ENSG00000106299
Uniprot IDs		A4D0W4 Q9UDR5	O00401
PDB IDs		5L76 5L78 5O1N 5O1O 5O1P	2FF3 2LNH 2VCP 4CC2 4CC7
Enriched GO Terms of Interacting Partners?
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