TRAP1 and EXT1

Number of citations of the paper that reports this interaction (PubMedID 10545594)
15

Data Source:
HPRD (two hybrid, in vitro)

		TRAP1	EXT1
Description		TNF receptor associated protein 1	exostosin glycosyltransferase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	RNA Binding Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Unfolded Protein Binding	Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Transferase Activity, Transferring Glycosyl Groups Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity
	Biological Process	Protein Folding Translational Attenuation Chaperone-mediated Protein Folding Negative Regulation Of Cellular Respiration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide	Skeletal System Development Ossification Glycosaminoglycan Biosynthetic Process Protein Glycosylation Signal Transduction Gastrulation Axon Guidance Endoderm Development Mesoderm Development Heparan Sulfate Proteoglycan Biosynthetic Process Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Olfactory Bulb Development Cellular Polysaccharide Biosynthetic Process Embryonic Skeletal Joint Development
Pathways		Respiratory electron transport	HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Drugs
Diseases			Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses Multiple exostoses
GWAS		Estimated glomerular filtration rate ( 31152163 31451708) Granulocyte count ( 27863252) Infliximab-induced mucosal healing in Crohn's disease ( 31039275) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Neutrophil count ( 27863252) Non-alcoholic fatty liver disease activity score ( 31311600) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Autism spectrum disorder ( 28540026) Common carotid intima-media thickness ( 29206233) Common carotid intima-media thickness in HIV infection ( 29206233) Depression in smokers ( 30219690) Endometrial cancer (Non-endometrioid histology) ( 30093612) Facial attractiveness (female raters) ( 30946739) General cognitive ability ( 29844566) Height ( 19893584) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Urate levels in obese individuals ( 25811787) White blood cell count (basophil) ( 29403010)
Interacting Genes		15 interacting genes: APP ESX1 EXT1 EXT2 HGS MCPH1 PSMC4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3	4 interacting genes: EXT2 FBXW7 NOTCH1 TRAP1
Entrez ID		10131	2131
HPRD ID		05868	00598
Ensembl ID		ENSG00000126602	ENSG00000182197
Uniprot IDs		A0A140VJY2 Q12931 Q53FS6	Q16394
PDB IDs		4Z1F 4Z1G 4Z1H 4Z1I 5F3K 5F5R 5HPH 5Y3N 5Y3O
Enriched GO Terms of Interacting Partners?
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