PDIA6 and VKORC1

Number of citations of the paper that reports this interaction (PubMedID 21103663)
7

Data Source:
BioGRID (two hybrid)

		PDIA6	VKORC1
Description		protein disulfide isomerase family A member 6	vitamin K epoxide reductase complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cell Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Peptide Disulfide Oxidoreductase Activity	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding
	Biological Process	Protein Folding IRE1-mediated Unfolded Protein Response Post-translational Protein Modification Cellular Protein Metabolic Process Cell Redox Homeostasis Oxidation-reduction Process	Blood Coagulation Response To Organonitrogen Compound Response To Organic Cyclic Compound Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Regulation Of Blood Coagulation Vitamin K Metabolic Process Response To Antibiotic Oxidation-reduction Process Bone Development
Pathways		XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Metabolism of vitamin K
Drugs			Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases			Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 20833655 19300499 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		14 interacting genes: ATP13A2 CASP8 CEP250 CLN8 CSNK2A1 LGALS9 MTNR1A MTNR1B NPC2 SLC2A4 SUMO4 TRIM14 UBE3A VKORC1	83 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CREB3 CXADR DCTPP1 DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		10130	79001
HPRD ID		07504	10540
Ensembl ID		ENSG00000143870	ENSG00000167397
Uniprot IDs		A0A384NPU5 Q15084	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs		1X5D 3VWW 3W8J 4EF0 4GWR
Enriched GO Terms of Interacting Partners?
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