RANBP9 and MKLN1

Number of citations of the paper that reports this interaction (PubMedID 27173435)
49

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		RANBP9	MKLN1
Description		RAN binding protein 9	muskelin 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane	Ubiquitin Ligase Complex Ruffle Nucleoplasm Cytoplasm Cytosol Cell Cortex Cell Junction Postsynapse
	Molecular Function	Protein Binding Ran GTPase Binding Enzyme Binding	Protein Homodimerization Activity
	Biological Process	MAPK Cascade Microtubule Nucleation Axon Guidance Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade	Regulation Of Receptor Internalization Cell-matrix Adhesion Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Reorganization
Pathways		L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling
Drugs
Diseases
GWAS		Breast cancer ( 29059683 23535729)	Asthma (childhood onset) ( 23829686) Bipolar disorder ( 31043756) Bipolar disorder (early onset) ( 27769005) Heel bone mineral density ( 30598549) Hyperglycemia in higher physical activity ( 30327367) Hypertension ( 28273873) Lung cancer in never smokers ( 28604730) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Pancreatic cancer ( 25086665) PR interval ( 30046033) Resting heart rate ( 27798624) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Systolic blood pressure ( 28135244) Vitamin D levels ( 25208829) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		56 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 CACNA1G CALB1 CBS CCND1 CDK11B CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LMNA MAPK6 MET MKLN1 MPHOSPH8 NCOA6 NCOR2 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 YPEL5	3 interacting genes: MAEA PTGER3 RANBP9
Entrez ID		10048	4289
HPRD ID		04835	16129
Ensembl ID		ENSG00000010017	ENSG00000128585
Uniprot IDs		A0A024QZW3 Q96S59	B4DG30 Q9UL63
PDB IDs		5JI7 5JI9 5JIU
Enriched GO Terms of Interacting Partners?
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