SH2D3C and CARD11

Number of citations of the paper that reports this interaction (PubMedID 16825666)
16

Data Source:
HPRD (in vivo)

		SH2D3C	CARD11
Description		SH2 domain containing 3C	caspase recruitment domain family member 11
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GO Annotations	Cellular Component	Cytoplasm Membrane	Immunological Synapse Cytoplasm Cytosol Plasma Membrane CBM Complex Membrane Raft Extracellular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Guanylate Kinase Activity Protein Binding CARD Domain Binding
	Biological Process	JNK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation	Positive Regulation Of Cytokine Production Stimulatory C-type Lectin Receptor Signaling Pathway Immunoglobulin Production I-kappaB Kinase/NF-kappaB Signaling B Cell Differentiation Positive Regulation Of B Cell Proliferation T Cell Costimulation Fc-epsilon Receptor Signaling Pathway TORC1 Signaling B Cell Proliferation Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Thymic T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Regulation Of B Cell Differentiation Regulation Of T Cell Differentiation GMP Metabolic Process GDP Metabolic Process Homeostasis Of Number Of Cells T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-2 Secretion
Pathways			Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling
Drugs
Diseases
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252)	Atopic dermatitis ( 23042114) Cadmium levels ( 26025379) Daytime sleep phenotypes ( 27126917) Dupuytren's disease ( 28886342) Intracranial aneurysm ( 29531279) Multiple sclerosis ( 31604244 24076602) Response to fenofibrate (total cholesterol levels) ( 27002377) Ulcerative colitis ( 23128233) White matter integrity ( 23218918)
Interacting Genes		11 interacting genes: BCAR1 CARD11 EFS EGFR EPHB2 GOLGA2 MAPK1 NEDD9 PTK2B SNCAIP SRC	15 interacting genes: BCL10 IKBKG MAP3K7 MAP4K1 PDPK1 PPP2CA PPP2R1A PRKCB PRKCQ RNF181 SH2D3C SRPK2 TAB1 WDR1 ZAP70
Entrez ID		10044	84433
HPRD ID		05284	06234
Ensembl ID		ENSG00000095370	ENSG00000198286
Uniprot IDs		B4DG32 Q8N5H7	A0A024R854 Q8TES3 Q9BXL7
PDB IDs		3T6G	4JUP 4LWD
Enriched GO Terms of Interacting Partners?
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