FRAT1 and LMAN2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		FRAT1	LMAN2
Description		FRAT regulator of WNT signaling pathway 1	lectin, mannose binding 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intracellular Membrane-bounded Organelle	Golgi Membrane Extracellular Space Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Integral Component Of Plasma Membrane Cell Surface COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Mannose Binding Carbohydrate Binding Heat Shock Protein Binding Metal Ion Binding
	Biological Process	Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Disassembly	ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Endoplasmic Reticulum Organization Golgi Organization Protein Transport Positive Regulation Of Phagocytosis
Pathways		Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane	COPII-mediated vesicle transport Cargo concentration in the ER
Drugs
Diseases
GWAS			Activated partial thromboplastin time ( 22703881) Allergic disease (asthma, hay fever or eczema) ( 29083406) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Blood protein levels ( 30072576) Chronic kidney disease ( 20383146) Metabolite levels (small molecules and protein measures) ( 27005778) Red blood cell count ( 27863252) Serum uric acid levels ( 30993211) Urinary calcium excretion ( 31993563) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: DVL1 GPRASP2 GRN GSK3B KCNK5 KRT18 LAMC3 LMAN2 LTBP4 PLSCR1 PSMA3 RABEP2 TDRD7	5 interacting genes: ATP13A2 FRAT1 MAPK9 SUPT5H TSPAN17
Entrez ID		10023	10960
HPRD ID		03935	17285
Ensembl ID		ENSG00000165879	ENSG00000169223
Uniprot IDs		Q92837	A0A384NPY7 Q12907
PDB IDs		1GNG 3ZRK 3ZRL 3ZRM 4AFJ 5OY4
Enriched GO Terms of Interacting Partners?
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