ADRB1

Description		adrenoceptor beta 1
Image
GO Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Schaffer Collateral - CA1 Synapse
	Molecular Function	Adrenergic Receptor Activity Beta-adrenergic Receptor Activity Beta1-adrenergic Receptor Activity Ras Guanyl-nucleotide Exchange Factor Activity Protein Binding PDZ Domain Binding Alpha-2A Adrenergic Receptor Binding Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Temperature Homeostasis Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Behavior Response To Cold Heat Generation Negative Regulation Of Multicellular Organism Growth Fear Response Positive Regulation Of GTPase Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Brown Fat Cell Differentiation Regulation Of Postsynaptic Membrane Potential Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Adrenoceptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Spermine Amphetamine Esmolol Betaxolol Bethanidine Isoetarine Cabergoline Metoprolol Amitriptyline Olanzapine Atenolol Norepinephrine Mirtazapine Timolol Phenylpropanolamine Loxapine Sotalol Carteolol Nortriptyline Propranolol Labetalol Bisoprolol Epinephrine Trimipramine Dobutamine Pseudoephedrine Alprenolol Terbutaline Salmeterol Pindolol Formoterol Salbutamol Isoprenaline Arbutamine Amiodarone Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Fenoterol Pirbuterol Bevantolol Practolol Penbutolol Ephedra Mephentermine Clenbuterol Oxprenolol Putrescine Spermidine Celiprolol Dronedarone Nebivolol Asenapine Droxidopa Bufuralol 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL Bopindolol Bupranolol Befunolol Vortioxetine Levobetaxolol Xamoterol
Diseases
GWAS		Birth weight ( 23202124 31043758 27680694) Blood pressure ( 21909110) Diastolic blood pressure ( 28135244 27841878 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Gaucher disease severity ( 22388998) High density lipoprotein cholesterol levels ( 29083408) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Systolic blood pressure ( 27841878 28739976 27618447 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		16 interacting genes: ADRA2A ARRB1 DLG1 DLG4 DLGAP2 GIPC1 GOPC GPRASP1 GPRASP2 GRB2 MAGI2 MAGI3 NOS1 SH3GL2 SH3GL3 SNTA1
Entrez ID		153
HPRD ID		00181
Ensembl ID		ENSG00000043591
Uniprot IDs		P08588
PDB IDs		2LSQ
Enriched GO Terms of Interacting Partners?
Tagcloud ?