TOMM70 and FOXC1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		TOMM70	FOXC1
Description		translocase of outer mitochondrial membrane 70	forkhead box C1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Integral Component Of Membrane Extracellular Exosome	Chromatin Heterochromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Sequence-specific DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Protein Targeting To Mitochondrion Macroautophagy Protein Import Into Mitochondrial Matrix Positive Regulation Of Interferon-beta Production Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Inner Membrane Cellular Response To Virus	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Ovarian Follicle Development Eye Development Ureteric Bud Development In Utero Embryonic Development Somitogenesis Kidney Development Lymph Vessel Development Endochondral Ossification Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Heart Development Cell Population Proliferation Germ Cell Migration Anatomical Structure Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Mesenchymal Cell Development Neural Crest Cell Development Cell Migration Negative Regulation Of Angiogenesis Cerebellum Development Cell Differentiation Collagen Fibril Organization Glycosaminoglycan Metabolic Process Lacrimal Gland Development Embryonic Heart Tube Development Maintenance Of Lens Transparency Vascular Endothelial Growth Factor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Camera-type Eye Development Positive Regulation Of DNA Binding Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Organ Growth Vascular Endothelial Growth Factor Receptor Signaling Pathway Paraxial Mesoderm Formation Artery Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Chemokine-mediated Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Glomerular Epithelium Development Blood Vessel Diameter Maintenance Negative Regulation Of Lymphangiogenesis Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Positive Regulation Of Core Promoter Binding Cellular Response To Chemokine
Pathways		Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases
Drugs
Diseases			Axenfeld-Rieger syndrome (ARS)
GWAS			Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Essential hypertension (time to event) ( 32589924) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 26752265) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 26752265 29891935) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010 31959993 30054594) Monobrow thickness ( 26926045) Non-response to citalopram or escitalopram and depression ( 27622933) Refractive error ( 32231278) Response to platinum-based agents ( 22020760) Systolic blood pressure ( 30224653)
Interacting Genes		7 interacting genes: HSP90AA1 HSPA1A HSPA1B HSPB1 IRF3 PRKN SNAPIN	1 interacting genes: HMGB1
Entrez ID		9868	2296
HPRD ID		16194	03054
Ensembl ID		ENSG00000154174	ENSG00000054598
Uniprot IDs		O94826	Q12948 W6CJ52
PDB IDs		7KDT
Enriched GO Terms of Interacting Partners?
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