TOMM70 and CTNNA2

Data Source:
BioGRID (proximity labelling technology)

		TOMM70	CTNNA2
Description		translocase of outer mitochondrial membrane 70	catenin alpha 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Integral Component Of Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Actin Cytoskeleton Catenin Complex Axon
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding	Structural Constituent Of Cytoskeleton Protein Binding Beta-catenin Binding Cadherin Binding Actin Filament Binding
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Protein Targeting To Mitochondrion Macroautophagy Protein Import Into Mitochondrial Matrix Positive Regulation Of Interferon-beta Production Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Inner Membrane Cellular Response To Virus	Cytoskeleton Organization Axonogenesis Regulation Of Neuron Projection Development Cell Migration Radial Glia Guided Migration Of Purkinje Cell Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendrite Morphogenesis Brain Morphogenesis Positive Regulation Of Muscle Cell Differentiation Regulation Of Synapse Structural Plasticity Prepulse Inhibition Cell-cell Adhesion Regulation Of Neuron Migration
Pathways		Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases	Myogenesis Myogenesis
Drugs
Diseases
GWAS			Adult body size ( 32376654) Alcohol consumption ( 28937693) Alcohol dependence or heroin dependence or methamphetamine dependence ( 31462767) Alzheimer's disease (cognitive decline) ( 23535033) Bipolar disorder ( 19416921) Body mass index ( 26426971 25673413) Bone mineral density (femoral neck) ( 26911590) Breast cancer ( 25824743) Cerebral microbleeds ( 31209788) Cerebrospinal fluid clusterin levels ( 26545630) Cleft palate ( 30452639) Cognitive function ( 25644384) Contrast sensitivity ( 24152035) Cooked vegetable consumption ( 32066663) Fish- and plant-related diet ( 32066663) Gut microbiota relative abundance (Bacteroides) ( 33208821) Mild influenza (H1N1) infection ( 26379185) Multisite chronic pain ( 31194737) Orthostatic hypotension ( 24124408) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Protein quantitative trait loci ( 18464913) Raw vegetable consumption ( 32066663) Refractive error ( 32231278) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to lurasidone in schizophrenia ( 29730043) Schizophrenia (MTAG) ( 32107650) Survival in pancreatic cancer ( 28470677)
Interacting Genes		7 interacting genes: HSP90AA1 HSPA1A HSPA1B HSPB1 IRF3 PRKN SNAPIN	2 interacting genes: CTNNBIP1 PTPN14
Entrez ID		9868	1496
HPRD ID		16194	00228
Ensembl ID		ENSG00000154174	ENSG00000066032
Uniprot IDs		O94826	F6KRI5 P26232 Q49AD3
PDB IDs		7KDT	6DUW
Enriched GO Terms of Interacting Partners?
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