CDC42BPB and MARK3

Data Source:
BioGRID (proximity labelling technology)

		CDC42BPB	MARK3
Description		CDC42 binding protein kinase beta	microtubule affinity regulating kinase 3
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Lamellipodium Cell Leading Edge Actomyosin Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Dendrite Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Protein-containing Complex Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Phosphorylation Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Migration Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Intracellular Signal Transduction	MAPK Cascade Microtubule Cytoskeleton Organization Protein Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-serine Autophosphorylation
Pathways			RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Fostamatinib
Diseases
GWAS		Body mass index ( 26426971) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 32888494) Refractive error ( 32231278)	Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Cutaneous melanoma or hair colour ( 32341527) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Optic disc size ( 31809533) PR interval ( 32439900) Systolic blood pressure ( 30224653 30578418) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CDC42 CDC42BPA MAP2K5 PPM1A PPP2CA PYGM RIPK1	30 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CHGB CLASP1 CLASP2 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ SAAL1 SFN TCEA2 TTR VPS11 YWHAG YWHAQ YWHAZ
Entrez ID		9578	4140
HPRD ID		08516	04058
Ensembl ID		ENSG00000198752	ENSG00000075413
Uniprot IDs		A0A024R6N2 Q86XZ8 Q9Y5S2	P27448 Q86U11
PDB IDs		3QFV 3TKU 4UAK 4UAL 5OTE 5OTF	2QNJ 3FE3
Enriched GO Terms of Interacting Partners?
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