CD28 and WBP2NL

Data Source:
BioGRID (affinity chromatography technology)

		CD28	WBP2NL
Description		CD28 molecule	WBP2 N-terminal like
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Protein Complex Involved In Cell Adhesion	Nucleus Perinuclear Theca Sperm Flagellum Sperm Head
	Molecular Function	Protease Binding Protein Binding Coreceptor Activity Protein Kinase Binding Identical Protein Binding	Transcription Coactivator Activity Protein Binding Chromatin DNA Binding WW Domain Binding
	Biological Process	Cytokine Production Positive Regulation Of Inflammatory Response To Antigenic Stimulus Humoral Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of T Cell Proliferation T Cell Activation Negative Regulation Of Apoptotic Process Negative Thymic T Cell Selection Regulatory T Cell Differentiation Positive Regulation Of Viral Genome Replication Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Defense Response To Virus By Virus T Cell Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway	Egg Activation Female Pronucleus Assembly Male Pronucleus Assembly Positive Regulation Of Transcription, DNA-templated Meiotic Cell Cycle Regulation Of Cytosolic Calcium Ion Concentration
Pathways		PIP3 activates AKT signaling Nef mediated downregulation of CD28 cell surface expression Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Graves' disease ( 21841780) Heschl's gyrus morphology ( 25130324) Inflammatory bowel disease ( 26192919) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602) Primary biliary cholangitis ( 28425483) Primary sclerosing cholangitis ( 23603763 27992413) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 26192919)	Autism spectrum disorder or schizophrenia ( 28540026) Breast size ( 22747683) Estimated glomerular filtration rate ( 31217584) Feeling tense ( 29500382) Intelligence ( 28530673) Isthmus-cingulate cortex volume ( 31530798) Platelet distribution width ( 27863252) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		17 interacting genes: CD247 CD4 CD80 CD86 DUSP14 GRAP2 GRB2 IL12A ITK LCK LRRC23 NSF PIK3CG PIK3R1 PIK3R2 PLCG1 PTPRC	1 interacting genes: FMR1
Entrez ID		940	164684
HPRD ID		01727	14512
Ensembl ID		ENSG00000178562	ENSG00000183066
Uniprot IDs		B4E0L1 P10747	Q6ICG8
PDB IDs		1YJD 3WA4 5AUL 5GJH 5GJI 6O8D
Enriched GO Terms of Interacting Partners?
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