CD83 and PAPSS2

Data Source:
BioGRID (biochemical)

		CD83	PAPSS2
Description		CD83 molecule	3'-phosphoadenosine 5'-phosphosulfate synthase 2
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Cytosol
	Molecular Function	Protein Binding	Adenylylsulfate Kinase Activity Sulfate Adenylyltransferase (ATP) Activity Protein Binding ATP Binding Nucleotidyltransferase Activity
	Biological Process	Defense Response Humoral Immune Response Signal Transduction Response To Organic Cyclic Compound Negative Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation	Sulfate Assimilation Skeletal System Development Phosphorylation 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process
Pathways			Transport and synthesis of PAPS Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Defective PAPSS2 causes SEMD-PA
Drugs
Diseases			SEMD, Pakistani type
GWAS		Breast cancer and/or colorectal cancer ( 29698419) California verbal learning test score ( 31596458) Chronotype ( 30696823) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 30423114 22446963 24390342)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Leisure-time exercise behaviour ( 19727025) Magnesium levels ( 26685716)
Interacting Genes		2 interacting genes: EIF4E FATE1	4 interacting genes: APP CEP19 DAPK1 HSF2BP
Entrez ID		9308	9060
HPRD ID		05170	04303
Ensembl ID		ENSG00000112149	ENSG00000198682
Uniprot IDs		A0A087WX61 Q01151	O95340 Q5TB52
PDB IDs		5MIX 5MJ0 5MJ1 5MJ2	2AX4
Enriched GO Terms of Interacting Partners?
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