SMC3 and CYP27B1

Data Source:
BioGRID (affinity chromatography technology)

		SMC3	CYP27B1
Description		structural maintenance of chromosomes 3	cytochrome P450 family 27 subfamily B member 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole	Cytoplasm Mitochondrion Mitochondrial Outer Membrane
	Molecular Function	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding	Calcidiol 1-monooxygenase Activity Iron Ion Binding Heme Binding Secalciferol 1-monooxygenase Activity
	Biological Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly	Vitamin Metabolic Process Calcium Ion Transport Negative Regulation Of Cell Population Proliferation Negative Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D 24-hydroxylase Activity Bone Mineralization Negative Regulation Of Cell Growth Regulation Of Bone Mineralization Response To Lipopolysaccharide Response To Vitamin D Response To Interferon-gamma Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Vitamin D Catabolic Process Response To Estrogen Positive Regulation Of Keratinocyte Differentiation Decidualization Calcium Ion Homeostasis G1 To G0 Transition Positive Regulation Of Vitamin D Receptor Signaling Pathway
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Vitamin D (calciferol) metabolism Vitamins Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Drugs			Alfacalcidol
Diseases		Cornelia de Lange syndrome (CdLS)	Type I diabetes mellitus
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041) Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)	Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 19525955 21833088)
Interacting Genes		18 interacting genes: APC CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B SUMO2 TRAF3IP1
Entrez ID		9126	1594
HPRD ID		05829	02031
Ensembl ID		ENSG00000108055	ENSG00000111012
Uniprot IDs		Q9UQE7	O15528
PDB IDs		6WG3 6WG4 6WG6 6WGE
Enriched GO Terms of Interacting Partners?
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