PAPSS2 and CD83

Data Source:
BioGRID (biochemical)

		PAPSS2	CD83
Description		3'-phosphoadenosine 5'-phosphosulfate synthase 2	CD83 molecule
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GO Annotations	Cellular Component	Cytosol	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Adenylylsulfate Kinase Activity Sulfate Adenylyltransferase (ATP) Activity Protein Binding ATP Binding Nucleotidyltransferase Activity	Protein Binding
	Biological Process	Sulfate Assimilation Skeletal System Development Phosphorylation 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process	Defense Response Humoral Immune Response Signal Transduction Response To Organic Cyclic Compound Negative Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Pathways		Transport and synthesis of PAPS Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Defective PAPSS2 causes SEMD-PA
Drugs
Diseases		SEMD, Pakistani type
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Leisure-time exercise behaviour ( 19727025) Magnesium levels ( 26685716)	Breast cancer and/or colorectal cancer ( 29698419) California verbal learning test score ( 31596458) Chronotype ( 30696823) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 30423114 22446963 24390342)
Interacting Genes		4 interacting genes: APP CEP19 DAPK1 HSF2BP	2 interacting genes: EIF4E FATE1
Entrez ID		9060	9308
HPRD ID		04303	05170
Ensembl ID		ENSG00000198682	ENSG00000112149
Uniprot IDs		O95340 Q5TB52	A0A087WX61 Q01151
PDB IDs		2AX4	5MIX 5MJ0 5MJ1 5MJ2
Enriched GO Terms of Interacting Partners?
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