ZPR1 and AP2A2

Data Source:
BioGRID (affinity chromatography technology)

		ZPR1	AP2A2
Description		ZPR1 zinc finger	adaptor related protein complex 2 subunit alpha 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body Axon Growth Cone Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Gemini Of Coiled Bodies	Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Receptor Tyrosine Kinase Binding Translation Initiation Factor Binding	Molecular_function Protein Binding Lipid Binding Protein Kinase Binding Clathrin Adaptor Activity Disordered Domain Specific Binding Cargo Adaptor Activity
	Biological Process	Microtubule Cytoskeleton Organization Inner Cell Mass Cell Proliferation Trophectodermal Cell Proliferation MRNA Processing Signal Transduction Cell Population Proliferation RNA Splicing Positive Regulation Of Gene Expression Spinal Cord Development Cajal Body Organization Regulation Of Myelination Positive Regulation Of RNA Splicing DNA Endoreduplication Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Growth Axon Development Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Apoptotic Process Involved In Development Pre-mRNA Catabolic Process Negative Regulation Of Motor Neuron Apoptotic Process	Intracellular Protein Transport Receptor-mediated Endocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Neutrophil Degranulation Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Clathrin-dependent Endocytosis
Pathways			Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Cholesterol ( 31902109) Coronary artery disease ( 29263402 29212778) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29403010) Low density lipoprotein cholesterol levels ( 29403010) Metabolic syndrome ( 30382898 31589552) Postprandial triglyceride levels ( 32603185) Postprandial triglyceride response to high fat diet meal ( 26256467) Total cholesterol levels ( 29615537) Triglyceride levels ( 29615537)	Adult asthma ( 27611488) Alzheimer's disease ( 30636644) Alzheimer's disease (late onset) ( 24162737) Asthma ( 31959851) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581)
Interacting Genes		6 interacting genes: CDK5RAP2 EEF1A1 EGFR MPP3 SNUPN SUMO4	18 interacting genes: AAGAB AMPH AP1S1 AP2B1 APP BIN1 DNAJC6 DNM1 EPN1 EPS15 HTT NLGN3 NUMB SHC1 SLC2A8 SMAD1 SNAP91 UBC
Entrez ID		8882	161
HPRD ID		04877	06256
Ensembl ID		ENSG00000109917	ENSG00000183020
Uniprot IDs		O75312	O94973
PDB IDs
Enriched GO Terms of Interacting Partners?
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