GMPS and FGFR3

Data Source:
BioGRID (affinity chromatography technology)

		GMPS	FGFR3
Description		guanine monophosphate synthase	fibroblast growth factor receptor 3
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GO Annotations	Cellular Component	Cytosol	Extracellular Region Nucleus Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Transport Vesicle Receptor Complex
	Molecular Function	GMP Synthase Activity GMP Synthase (glutamine-hydrolyzing) Activity ATP Binding Pyrophosphatase Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Fibroblast Growth Factor Binding Identical Protein Binding
	Biological Process	GMP Biosynthetic Process Glutamine Metabolic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process	MAPK Cascade Skeletal System Development Endochondral Ossification Chondrocyte Differentiation Endochondral Bone Growth Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Peptidyl-tyrosine Phosphorylation Bone Mineralization Positive Regulation Of Kinase Activity Chondrocyte Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Negative Regulation Of Developmental Growth Positive Regulation Of Protein Kinase B Signaling Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Pathways		Purine ribonucleoside monophosphate biosynthesis	Signaling by activated point mutants of FGFR3 FGFR3 mutant receptor activation t(4;14) translocations of FGFR3 Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer
Drugs		Glutamic acid	XL999 Pazopanib Ponatinib Lenvatinib Nintedanib Fostamatinib Erdafitinib Pemigatinib Selpercatinib
Diseases			Bladder cancer Multiple myeloma Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome FGFR3-related short limb skeletal dysplasias, including: Achondroplasia; Hypochondroplasia; Thanatophoric dysplasia, type 1; Thanatophoric dysplasia, type 2; Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN) CATSHL syndrome
GWAS		Blood metabolite levels ( 27453504) Cardiorespiratory fitness (800m run time) ( 32572135)	Bladder cancer ( 24163127 20972438) Blood protein levels ( 30072576) Metabolite levels ( 23823483) Urinary bladder cancer ( 20348956)
Interacting Genes		2 interacting genes: AGPAT2 SUMO4	43 interacting genes: ANOS1 ARAP1 ATF3 BORA C6orf47 CCDC17 CEP126 CHGB CTSK EPHA4 ERBB2 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GPSM3 GRB2 GTF3C1 HBZ HNRNPL KRT8 NDUFS6 NECTIN1 POLA2 PTK2B RADIL RNF130 RPL8 RPS6KA3 SH2B1 SLC25A6 SMG7 SRPK2 STAT1 STAT3
Entrez ID		8833	2261
HPRD ID		10927	00624
Ensembl ID		ENSG00000163655	ENSG00000068078
Uniprot IDs		A0A140VJK6 P49915	P22607 Q0IJ44
PDB IDs		2VPI 2VXO	1RY7 2LZL 4K33 6LVM 6PNX
Enriched GO Terms of Interacting Partners?
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