TNFSF14 and SLC38A3

Data Source:
BioGRID (affinity chromatography technology)

		TNFSF14	SLC38A3
Description		TNF superfamily member 14	solute carrier family 38 member 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	L-histidine Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-asparagine Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity Symporter Activity Antiporter Activity
	Biological Process	Apoptotic Process Immune Response Signal Transduction T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of NIK/NF-kappaB Signaling	Amino Acid Transmembrane Transport Sodium Ion Transport Amino Acid Transport Asparagine Transport Glutamine Transport Brain Development Female Pregnancy L-alanine Transport Histidine Transport Cellular Response To Potassium Ion Starvation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Acidic PH L-histidine Transmembrane Transport Transport Across Blood-brain Barrier Positive Regulation Of Glutamine Transport
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Amino acid transport across the plasma membrane
Drugs			Histidine Asparagine
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 24076602 21833088)	Body mass index ( 26426971) Conotruncal heart defects (maternal effects) ( 28468790) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sleep duration (short sleep) ( 30846698) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		22 interacting genes: ADAM33 ADIPOQ APP BMP10 CLDN11 CLDN19 CXCL9 JAGN1 LHFPL3 LTB LTBR MAL OLFM4 PLLP PTTG1IP SEC22A SEC23A SYS1 TMEM11 TNFRSF14 TNFRSF6B UPK2	3 interacting genes: COL6A2 HMGN1 SETDB1
Entrez ID		8740	10991
HPRD ID		05157	11980
Ensembl ID		ENSG00000125735	ENSG00000188338
Uniprot IDs		O43557	Q99624
PDB IDs		4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU
Enriched GO Terms of Interacting Partners?
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