VAMP4 and CYP1A1

Data Source:
BioGRID (affinity chromatography technology)

		VAMP4	CYP1A1
Description		vesicle associated membrane protein 4	cytochrome P450 family 1 subfamily A member 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Synaptic Vesicle Cell Surface Transport Vesicle Integral Component Of Synaptic Vesicle Membrane Clathrin-coated Vesicle Membrane SNARE Complex Trans-Golgi Network Membrane	Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonic Acid Monooxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Flavonoid 3'-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Demethylase Activity Hsp90 Protein Binding Aromatase Activity Vitamin D 24-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	Microtubule Cytoskeleton Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Synaptic Vesicle To Endosome Fusion SNARE Complex Assembly Golgi To Plasma Membrane Protein Transport Membrane Organization Golgi Ribbon Formation Regulation Of Synaptic Vesicle Endocytosis	Response To Hypoxia Lipid Hydroxylation DNA Methylation Fatty Acid Metabolic Process Steroid Biosynthetic Process Porphyrin-containing Compound Metabolic Process Aging Steroid Metabolic Process Estrogen Metabolic Process Cell Population Proliferation Amine Metabolic Process Response To Wounding Response To Virus Response To Nematode Response To Herbicide Ethylene Metabolic Process Coumarin Metabolic Process Flavonoid Metabolic Process Response To Iron(III) Ion Insecticide Metabolic Process Drug Metabolic Process Regulation Of Lipid Metabolic Process Dibenzo-p-dioxin Catabolic Process Epoxygenase P450 Pathway Response To Food Response To Lipopolysaccharide Response To Vitamin A Response To Immobilization Stress Vitamin D Metabolic Process Response To Drug Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process 9-cis-retinoic Acid Biosynthetic Process Camera-type Eye Development Response To Antibiotic Response To Arsenic-containing Substance Digestive Tract Development Hydrogen Peroxide Biosynthetic Process Response To Hyperoxia Maternal Process Involved In Parturition Hepatocyte Differentiation Demethylation Cellular Response To Copper Ion Cellular Response To Organic Cyclic Compound Omega-hydroxylase P450 Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	PPARA activates gene expression Xenobiotics Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of protectins
Drugs			2-Methoxyestradiol Indirubin Nabiximols
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal atrophy ( 25625606) Metabolite levels ( 23823483) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Caffeine consumption ( 21490707) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Clozapine concentration in schizophrenia ( 32555152) Coffee consumption ( 21876539 21357676 31046077 25288136) Coffee consumption (cups per day) ( 31837886 25288136) Diastolic blood pressure ( 26390057 19430483 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Estimated glomerular filtration rate ( 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Microalbuminuria ( 31511532) Plasma clozapine levels in treatment-resistant schizophrenia ( 30922102) Platelet distribution width ( 27863252) Relative carbohydrate intake ( 32393786) Sweet beverage consumption ( 31046077) Systolic blood pressure ( 21909115 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Tea consumption ( 31046077) Urate levels ( 31578528) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378 31511532) Urinary potassium excretion ( 31409800) Urinary sodium excretion ( 31409800)
Interacting Genes		45 interacting genes: ANKS6 AP1M1 AQP6 ARL13B BCL2L13 CISD2 CPLX4 CSNK2A1 CYB5R3 DNAJC5 EBP ELOVL4 ERGIC3 EVI2B FAM209A FAM210B GPR152 GPX8 KASH5 LDLRAD1 LEUTX MFF MGST3 MTIF3 PACS1 PSCA PTGES REEP4 RETREG3 SAR1A SEC11C SLC10A6 SNAP29 SSMEM1 STOM STX16 STX1A STX4 STX6 SYT2 TM4SF19 TMEM205 TMEM51 TMX2 TRIM54	2 interacting genes: CMTM5 CYB5A
Entrez ID		8674	1543
HPRD ID		06070	00148
Ensembl ID		ENSG00000117533	ENSG00000140465
Uniprot IDs		O75379 Q6IAZ3	A0N0X8 E7EMT5 P04798
PDB IDs			4I8V 6DWM 6DWN 6O5Y 6UDL 6UDM
Enriched GO Terms of Interacting Partners?
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