CUL3 and ZAP70

Data Source:
BioGRID (proximity labelling technology)

		CUL3	ZAP70
Description		cullin 3	zeta chain of T cell receptor associated protein kinase 70
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GO Annotations	Cellular Component	Golgi Membrane Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Polar Microtubule Cytosol Plasma Membrane Membrane Cullin-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Sperm Flagellum Extracellular Exosome Mitotic Spindle	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	Ubiquitin-protein Transferase Activity Notch Binding Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Protein Polyubiquitination Trophectodermal Cellular Morphogenesis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Metaphase Plate Congression Integrin-mediated Signaling Pathway Gastrulation Positive Regulation Of Cell Population Proliferation Wnt Signaling Pathway Cell Migration Protein Ubiquitination Stem Cell Division Cell Projection Organization Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Fibroblast Apoptotic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Protein Autoubiquitination Nuclear Protein Quality Control By The Ubiquitin-proteasome System Liver Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Phase Transition	Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration
Pathways		Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation	Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules
Drugs			Staurosporine Fostamatinib
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) General risk tolerance (MTAG) ( 30643258) Response to bupropion and depression ( 27622933) Schizophrenia ( 28991256 25056061 29483656 30285260) Sensorimotor dexterity ( 31596458) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		78 interacting genes: ABTB1 ABTB2 ACLY APP ARHGEF12 BTBD1 BTBD10 BTBD2 BTBD3 BTBD6 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 CLK1 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 DYRK4 EFNB1 ELOC FOLR1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GPS1 HLA-DMB HSF2 KCTD10 KCTD11 KCTD13 KCTD17 KCTD5 KCTD6 KCTD7 KCTD9 KEAP1 KLHL12 KLHL2 KLHL3 KLHL42 MAP1LC3B MAP1LC3C MAT2A MTNR1A MTNR1B NEDD8 OLIG2 PDCD6 PDIA2 PEF1 RBBP8 RBX1 RCBTB1 RCBTB2 RHOBTB3 RIT1 RNF7 SHKBP1 SPOP SUMO2 SUMO3 UBASH3B UBC UBE2D1 UBE2D2 UBE2E1 UBE2E2 UBE2E3 UBE2R2 WNT7B ZMAT4	66 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB2 ERBB3 ERBB4 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 KIT LAT LAX1 LCK LCP2 LRRK2 MET MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1
Entrez ID		8452	7535
HPRD ID		09123	01495
Ensembl ID		ENSG00000036257	ENSG00000115085
Uniprot IDs		A0A024R475 B7Z600 Q13618	P43403
PDB IDs		2MYL 2MYM 4AP2 4APF 4EOZ 4HXI 5NLB 6I2M	1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76
Enriched GO Terms of Interacting Partners?
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