ARID5B and NRBF2

Data Source:
HPRD (in vitro)

		ARID5B	NRBF2
Description		AT-rich interaction domain 5B	nuclear receptor binding factor 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleoplasm Cytoplasm Autophagosome Cytoplasmic Vesicle Phosphatidylinositol 3-kinase Complex, Class III
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coactivator Activity Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Liver Development Regulation Of Transcription By RNA Polymerase II Nitrogen Compound Metabolic Process Male Gonad Development Female Gonad Development Post-embryonic Development Fibroblast Migration Adrenal Gland Development Multicellular Organism Growth Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Platelet-derived Growth Factor Receptor Signaling Pathway Cell Development Muscle Organ Morphogenesis Skeletal System Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Roof Of Mouth Development Face Morphogenesis Adipose Tissue Development Fat Pad Development Cellular Response To Leukemia Inhibitory Factor	Transcription Initiation From RNA Polymerase II Promoter Autophagy Response To Endoplasmic Reticulum Stress Regulation Of Lipid Kinase Activity
Pathways		HDMs demethylate histones
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612 28817678 22076464 25310577 23512250 19684603 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) Autoimmune thyroid disease ( 32581359) Automobile speeding propensity ( 30643258) B-cell acute lymphoblastic leukaemia ( 31767839) Blood urea nitrogen levels ( 31152163) Central corneal thickness ( 32528159 31798171 29760442 30894546) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Corneal resistance factor ( 30894546) Corneal structure ( 23291589) Diastolic blood pressure ( 19430483) Estimated glomerular filtration rate ( 31152163) Gout ( 32238385) Heel bone mineral density ( 30598549) Height ( 31562340) Intraocular pressure ( 29617998 29235454) Intraocular pressure (Goldman correlated) ( 30894546) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Plateletcrit ( 32888494 27863252) Reaction time ( 29844566) Response to haloperidol in psychosis ( 24751813) Rheumatoid arthritis ( 30423114 22446963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Serum total protein level ( 23022100) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 27399966 23273568 26502338) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 32499647) Vitiligo ( 27723757)	Atrial fibrillation ( 30061737) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 24026423) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell count ( 32888494) Schizophrenia ( 28991256 30285260) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes			14 interacting genes: C1orf216 CCNC CDC23 HNF4A IKBKG KDM1A PIK3R4 PPARA PRKAA2 RARA RHOU RPTOR RXRA THRB
Entrez ID		84159	29982
HPRD ID		18880	11401
Ensembl ID		ENSG00000150347	ENSG00000148572
Uniprot IDs		Q14865	Q96F24
PDB IDs		1IG6 2OEH	4ZEY
Enriched GO Terms of Interacting Partners?
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