ZNF239 and MTHFR

Data Source:
BioGRID (proximity labelling technology)

		ZNF239	MTHFR
Description		zinc finger protein 239	methylenetetrahydrofolate reductase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytosol Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding RNA Binding Protein Binding Metal Ion Binding	Methylenetetrahydrofolate Reductase (NAD(P)H) Activity Protein-containing Complex Binding Flavin Adenine Dinucleotide Binding NADP Binding FAD Binding Modified Amino Acid Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Response To Hypoxia Neural Tube Closure Methionine Metabolic Process Methionine Biosynthetic Process Regulation Of Histone Methylation Response To Vitamin B2 Tetrahydrofolate Interconversion Response To Drug Response To Amino Acid S-adenosylmethionine Metabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process Response To Folic Acid Response To Interleukin-1 Heterochromatin Maintenance
Pathways			Metabolism of folate and pterines
Drugs			Cyanocobalamin Tetrahydrofolic acid
Diseases			Spina bifida Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Homocystinuria
GWAS			Atrial fibrillation ( 19597492) Blood pressure ( 21909110) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 28739976 27618452 29615537) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Folate pathway vitamin levels ( 19744961) High altitude adaptation ( 28373541) Homocysteine levels ( 23824729 20031578 23696881) Hypertension ( 31879980) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (calcium channel blockers) ( 31015401) Midregional pro atrial natriuretic peptide levels ( 29237677) Moyamoya disease ( 29273593) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Plasma homocysteine levels ( 30339177) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Red blood cell folate levels ( 30339177) Serum folate levels ( 30339177 29953918) Systolic blood pressure ( 19430483 27841878 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)
Interacting Genes		6 interacting genes: CARD10 CEP70 KRTAP10-6 LMNA MTUS2 WTAP	1 interacting genes: LSM8
Entrez ID		8187	4524
HPRD ID		03044	06158
Ensembl ID		ENSG00000196793	ENSG00000177000
Uniprot IDs		Q16600	P42898 Q59GJ6 Q5SNW7 Q8IU67
PDB IDs			6FCX
Enriched GO Terms of Interacting Partners?
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