LMAN2L and USP39

Data Source:
HPRD (in vitro)

		LMAN2L	USP39
Description		lectin, mannose binding 2 like	ubiquitin specific peptidase 39
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Integral Component Of Membrane COPII-coated ER To Golgi Transport Vesicle	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Protein Binding Mannose Binding Metal Ion Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding
	Biological Process	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Golgi Organization Protein Transport	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing Cell Cycle RNA Splicing Protein Deubiquitination Protein Phosphopantetheinylation Cell Division
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 22182935 21926972 31043756 28072414 20351715) Blood protein levels ( 30072576 29875488)	Neurofibrillary tangles ( 31497858)
Interacting Genes		2 interacting genes: MAL ZDHHC17	14 interacting genes: ACVR1 APP CHEK2 LRRK2 SAE1 SP1 SRPK1 SRPK2 TRAF6 TRIM25 TRIM26 TRIM39 TRIM5 TRIM8
Entrez ID		81562	10713
HPRD ID		17286	07165
Ensembl ID		ENSG00000114988	ENSG00000168883
Uniprot IDs		B4DI83 B4DVH1 B4E308 Q9H0V9	A0A087X1B2 B3KMG1 B3KPG7 B7Z7L9 Q53GS9
PDB IDs			3JCR 6AH0 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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