NUP214 and CHST6

Data Source:
BioGRID (proximity labelling technology)

		NUP214	CHST6
Description		nucleoporin 214	carbohydrate sulfotransferase 6
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Cytosol Host Cell Cytoplasmic Side Of Nuclear Pore	Golgi Membrane Golgi Apparatus Trans-Golgi Network Integral Component Of Membrane
	Molecular Function	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	N-acetylglucosamine 6-O-sulfotransferase Activity
	Biological Process	Mitotic Cell Cycle Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of MRNA Stability Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat	Carbohydrate Metabolic Process N-acetylglucosamine Metabolic Process Sulfur Compound Metabolic Process Keratan Sulfate Biosynthetic Process
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events	Keratan sulfate biosynthesis Defective CHST6 causes MCDC1
Drugs
Diseases			Macular corneal dystrophy (MCD); Corneal dystrophy Groenouw type II; Fehr corneal dystrophy
GWAS		Aspartate aminotransferase levels ( 31219225)	Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Dupuytren's disease ( 28886342) Pancreatic cancer ( 25086665)
Interacting Genes		20 interacting genes: APC CLEC4G DDX19B IPO5 NFX1 NUP107 NUP42 NUP62 NUP88 NXF1 NXF2 SMAD2 SMAD3 SMAD4 SUMO2 TNPO1 XPO1 XPO5 XPOT ZFP36
Entrez ID		8021	4166
HPRD ID		00258	05597
Ensembl ID		ENSG00000126883	ENSG00000183196
Uniprot IDs		B7ZAV2 P35658	Q9GZX3
PDB IDs		2OIT 3FHC 3FMO 3FMP 5DIS
Enriched GO Terms of Interacting Partners?
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