ZYG11B and ARPC2

Data Source:
BioGRID (affinity chromatography technology)

		ZYG11B	ARPC2
Description		zyg-11 family member B, cell cycle regulator	actin related protein 2/3 complex subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Cul2-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Endosome Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Lamellipodium Site Of Double-strand Break Muscle Cell Projection Membrane Neuron Projection Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Membrane Organization Actin Polymerization-dependent Cell Motility Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Monocyte percentage of white cells ( 32888494)	Inflammatory bowel disease ( 28067908 23128233) Mean platelet volume ( 32888494 27863252) Neutrophil count ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) White blood cell count ( 25096241 29403010)
Interacting Genes		4 interacting genes: CUL2 ELOB ELOC GBF1	6 interacting genes: ACTR3 ARPC1B ARPC4 AURKA CORO1B WAS
Entrez ID		79699	10109
HPRD ID		13356	10367
Ensembl ID		ENSG00000162378	ENSG00000163466
Uniprot IDs		A8DPD7 B4DK95 Q9C0D3	A0A024R408 O15144 Q53R19
PDB IDs			6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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