UNG and KERA

Data Source:
BioGRID (affinity chromatography technology)

		UNG	KERA
Description		uracil DNA glycosylase	keratocan
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function	Damaged DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Ribosomal Small Subunit Binding	Molecular_function
	Biological Process	DNA Repair Base-excision Repair Viral Process Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of Apoptotic Process Depyrimidination Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal	Visual Perception Keratan Sulfate Biosynthetic Process Keratan Sulfate Catabolic Process Response To Stimulus Cornea Development In Camera-type Eye
Pathways			Keratan sulfate biosynthesis Keratan sulfate degradation Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs		4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid
Diseases		Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3	Cornea plana congenita
GWAS		Feeling miserable ( 29500382) Feeling worry ( 29500382) Neurociticism ( 29500382) Worry too long after an embarrassing experience ( 29500382)	Pre-treatment viral load in HIV-1 infection ( 31219150) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure (alcohol consumption interaction) ( 24376456)
Interacting Genes		5 interacting genes: APP CAPN11 PCNA RPA2 SEZ6L2
Entrez ID		7374	11081
HPRD ID		01881	04477
Ensembl ID		ENSG00000076248	ENSG00000139330
Uniprot IDs		E5KTA5 E5KTA6 P13051	O60938
PDB IDs		1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7
Enriched GO Terms of Interacting Partners?
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