TESK1 and IL17RA

Data Source:
BioGRID (affinity chromatography technology)

		TESK1	IL17RA
Description		testis associated actin remodelling kinase 1	interleukin 17 receptor A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Protein Kinase Binding Metal Ion Binding	Protein Binding Interleukin-17 Receptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Spermatogenesis Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Negative Regulation Of Protein Autophosphorylation Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Phosphorylation Positive Regulation Of Stress Fiber Assembly Establishment Of Vesicle Localization Negative Regulation Of Protein Serine/threonine Kinase Activity Glomerular Visceral Epithelial Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly	Adaptive Immune Response Inflammatory Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Innate Immune Response Fibroblast Activation Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Pathways		Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Interleukin-17 signaling
Drugs		Fostamatinib
Diseases			Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS			Blood protein levels ( 30072576 29875488 28240269) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Heschl's gyrus morphology ( 25130324) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) White blood cell count ( 32888494 27863252)
Interacting Genes		7 interacting genes: ABCB4 ARAF CFL1 PFKL SPRY4 YWHAB YY1	2 interacting genes: IL17A MTDH
Entrez ID		7016	23765
HPRD ID		03470	10399
Ensembl ID		ENSG00000107140	ENSG00000177663
Uniprot IDs		Q15569 Q8NFJ4	Q96F46
PDB IDs			3JVF 4HSA 4NUX 5N9B 5NAN
Enriched GO Terms of Interacting Partners?
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