BTF3 and PTGIS

Data Source:
BioGRID (affinity chromatography technology)

		BTF3	PTGIS
Description		basic transcription factor 3	prostaglandin I2 synthase
Image
GO Annotations	Cellular Component	Nucleus Cytosol Nascent Polypeptide-associated Complex Polysomal Ribosome	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Caveola Integral Component Of Membrane
	Molecular Function	RNA Binding Protein Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Prostaglandin-I Synthase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	In Utero Embryonic Development Transcription By RNA Polymerase II Protein Transport	Prostaglandin Biosynthetic Process Icosanoid Metabolic Process Cyclooxygenase Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis
Pathways			Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Nicotinamide salvaging Eicosanoids Sterols are 12-hydroxylated by CYP8B1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs			Phenylbutazone Epoprostenol (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid
Diseases
GWAS		Eyebrow thickness ( 26926045) Monobrow thickness ( 26926045)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		13 interacting genes: APP CDC42 CSNK2B IFTAP MED21 NAA40 NMT2 NOTO POLR2B SMYD2 TXLNA TXLNB ZDHHC17	3 interacting genes: APP PTGS1 PTGS2
Entrez ID		689	5740
HPRD ID		03966	09046
Ensembl ID		ENSG00000145741	ENSG00000124212
Uniprot IDs		P20290	Q16647
PDB IDs		3LKX 3MCB	2IAG 3B6H
Enriched GO Terms of Interacting Partners?
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