STK4 and EPPK1

Data Source:
BioGRID (affinity chromatography technology)

		STK4	EPPK1
Description		serine/threonine kinase 4	epiplakin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex	Cytoplasm Cytoskeleton Intermediate Filament Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Cell Junction Hemidesmosome Cell Projection Keratin Filament Cell Periphery Perinucleolar Compartment
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Binding Structural Molecule Activity Intermediate Filament Binding Keratin Filament Binding
	Biological Process	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Population Proliferation Peptidyl-serine Phosphorylation Keratinocyte Differentiation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Binding Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Protein Stabilization Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process	Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Cell Migration Wound Healing Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Bundle Assembly Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Keratinocyte Migration Negative Regulation Of Wound Healing Regulation Of Epithelium Regeneration
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Mean platelet volume ( 32888494) Platelet count ( 32888494)	Knee osteoarthritis ( 28916551) Multiple sclerosis ( 31604244)
Interacting Genes		23 interacting genes: AKT1 CASP3 CNKSR1 CSN1S1 DAXX DDIT4L H2BC21 IL2RG KEAP1 LATS1 MARK2 MBP NEDD4 PICK1 RASSF1 RASSF5 RNF31 SAV1 SGMS1 SIRT1 STK3 THAP12 TP53	3 interacting genes: EGFR SUMO2 UCHL5
Entrez ID		6789	83481
HPRD ID		05395	06500
Ensembl ID		ENSG00000101109	ENSG00000261150
Uniprot IDs		Q13043	P58107
PDB IDs		2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT
Enriched GO Terms of Interacting Partners?
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