SOAT1 and TNFSF4

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (in vitro, two hybrid)

		SOAT1	TNFSF4
Description		sterol O-acyltransferase 1	TNF superfamily member 4
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Fatty-acyl-CoA Binding Sterol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Cholesterol Binding Cholesterol O-acyltransferase Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding
	Biological Process	Cholesterol Metabolic Process Macrophage Derived Foam Cell Differentiation Cholesterol Storage Cholesterol Efflux Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Cholesterol Esterification Cholesterol Homeostasis Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process	Positive Regulation Of Cytokine Production Defense Response To Nematode Acute Inflammatory Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Positive Regulation Of Type 2 Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Inflammatory Response Immune Response Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Tumor Necrosis Factor-mediated Signaling Pathway Memory T Cell Activation T-helper 2 Cell Activation Response To Nitrogen Dioxide Positive Regulation Of T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus Chemokine (C-C Motif) Ligand 11 Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes
Pathways		LDL clearance	TNFs bind their physiological receptors
Drugs		Ezetimibe Hesperetin
Diseases
GWAS		Metabolite levels ( 23823483)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25337690) Asthma ( 31361310 30929738 27182965 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 20190752 24999842) Crohn's disease ( 21102463) Diabetic retinopathy ( 21441570) IgA levels ( 28628107) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Vein graft stenosis in coronary artery bypass grafting ( 25881214)
Interacting Genes		1 interacting genes: TERF1	2 interacting genes: TNFRSF4 TRAF2
Entrez ID		6646	7292
HPRD ID		00033	04668
Ensembl ID		ENSG00000057252	ENSG00000117586
Uniprot IDs		P35610	A0A024R937 P23510
PDB IDs		6L47 6L48 6P2J 6P2P 6VUM	2HEV
Enriched GO Terms of Interacting Partners?
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