XCL1 and TNFSF18

Data Source:
BioGRID (affinity chromatography technology)

		XCL1	TNFSF18
Description		X-C motif chemokine ligand 1	TNF superfamily member 18
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Protein Binding Chemokine Activity Chemokine Receptor Binding Protein Homodimerization Activity CCR Chemokine Receptor Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of T Cell Cytokine Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Positive Regulation Of T Cell Chemotaxis Neutrophil Chemotaxis Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-10 Production Mature Natural Killer Cell Chemotaxis Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of GTPase Activity Negative Regulation Of Transcription, DNA-templated Lymphocyte Chemotaxis Regulation Of Inflammatory Response Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granzyme B Production Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Thymocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of B Cell Chemotaxis Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation	Adaptive Immune Response T Cell Proliferation Involved In Immune Response Positive Regulation Of Leukocyte Migration Signal Transduction Cell-cell Signaling Positive Regulation Of Macrophage Chemotaxis Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of T-helper 17 Cell Lineage Commitment Regulation Of Dendritic Cell Chemotaxis
Pathways		Chemokine receptors bind chemokines G alpha (q) signalling events	TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Metabolite levels ( 23823483)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25608926) Asthma ( 30929738 27182965) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 22057235 20190752 24999842) Crohn's disease ( 21102463 23128233) Itch intensity from mosquito bite ( 28199695) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		19 interacting genes: CCL11 CCL13 CCL21 CCL24 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL9 KRTAP10-3 PF4 PF4V1 VCAN XCR1	2 interacting genes: EXOC3L2 TNFRSF18
Entrez ID		6375	8995
HPRD ID		02595	04874
Ensembl ID		ENSG00000143184	ENSG00000120337
Uniprot IDs		P47992	A0A0U5JXL4 Q9UNG2
PDB IDs		1J8I 1J9O 2HDM 2JP1 2N54 2NYZ	2Q1M 2R30 2R32 3B93 3B94
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?