RFC2 and EIF4H

Data Source:
BioGRID (two hybrid, two hybrid)

		RFC2	EIF4H
Description		replication factor C subunit 2	eukaryotic translation initiation factor 4H
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Ctf18 RFC-like Complex	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Clamp Loader Activity Protein Binding ATP Binding Single-stranded DNA Helicase Activity Enzyme Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding Cadherin Binding
	Biological Process	DNA Replication DNA-dependent DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding Nucleotide-excision Repair, DNA Incision Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Error-free Translesion Synthesis Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of Signal Transduction By P53 Class Mediator	Formation Of Translation Preinitiation Complex Translational Initiation Regulation Of Translational Initiation Viral Process Sexual Reproduction Developmental Growth Eukaryotic Translation Initiation Factor 4F Complex Assembly
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS
Interacting Genes		12 interacting genes: HGS PCNA PRKAR1A PSMA1 RAD17 RAD18 RFC1 RFC4 RFC5 SUMO2 YOD1 ZIC1	7 interacting genes: C11orf68 DDIT4L DLG3 FBXO17 LNX1 PICK1 SPG21
Entrez ID		5982	7458
HPRD ID		02675	11940
Ensembl ID		ENSG00000049541	ENSG00000106682
Uniprot IDs		A0A087WVY3 P35250 Q75MT5	Q15056
PDB IDs		6VVO
Enriched GO Terms of Interacting Partners?
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