PTPN2 and COLEC12

Data Source:
BioGRID (biochemical)

		PTPN2	COLEC12
Description		protein tyrosine phosphatase non-receptor type 2	collectin subfamily member 12
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GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane	Collagen Trimer Extracellular Space Plasma Membrane Integral Component Of Membrane Endocytic Vesicle Membrane Extracellular Matrix
	Molecular Function	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Protein Kinase Binding Syntaxin Binding Receptor Tyrosine Kinase Binding STAT Family Protein Binding	Scavenger Receptor Activity Galactose Binding Low-density Lipoprotein Particle Binding Pattern Recognition Receptor Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipid Storage B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Glucose Homeostasis Negative Regulation Of Macrophage Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Chemotaxis Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-2-mediated Signaling Pathway Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Receptor-mediated Endocytosis Phagocytosis, Recognition Defense Response Carbohydrate Mediated Signaling Toll-like Receptor 3 Signaling Pathway Defense Response To Bacterium Innate Immune Response Regulation Of Immune Response Positive Regulation Of Cell Adhesion Molecule Production Cellular Response To Exogenous DsRNA
Pathways		Negative regulation of MET activity Interleukin-37 signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Scavenging by Class A Receptors
Drugs
Diseases		Type I diabetes mellitus
GWAS		Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Body mass index ( 25673413) C-reactive protein levels ( 30388399 21300955) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 25489960 28067908 17554261 17554300 21102463) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Esophageal cancer (squamous cell) ( 22960999) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lead levels in blood ( 25820613) Lymphocyte counts ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Psoriasis ( 28537254) Red blood cell count ( 32888494) Rheumatoid arthritis ( 30423114 22446963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Selective IgA deficiency ( 27723758) Type 1 diabetes ( 21829393 25751624 19430480 17554260 18978792)	Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Blood protein levels ( 30072576 29875488) Coenzyme Q10 levels ( 27149984) Metabolic syndrome ( 29212154) Obesity-related traits ( 23251661) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		23 interacting genes: CDK1 CDK2 CDK5 EGFR FAM220A FKBP4 GHR GJB1 INSR ITGA1 JAK1 JAK3 KPNB1 OCLN PDGFRB SHC1 SRC STAT1 STAT3 STAT5A STAT5B STX17 UBC	3 interacting genes: APP EXOC1 FBXO7
Entrez ID		5771	81035
HPRD ID		06768	06358
Ensembl ID		ENSG00000175354	ENSG00000158270
Uniprot IDs		A8K3N4 D3DUJ3 K7EQG9 P17706 Q59F91	Q5KU26
PDB IDs		1L8K	2OX8
Enriched GO Terms of Interacting Partners?
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