PRL and SCARB1

Data Source:
BioGRID (biochemical)

		PRL	SCARB1
Description		prolactin	scavenger receptor class B member 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Lumen	Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell Surface Endocytic Vesicle Membrane Microvillus Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Prolactin Receptor Binding Hormone Activity Protein Binding	Lipopolysaccharide Binding Amyloid-beta Binding Virus Receptor Activity Phosphatidylserine Binding Lipopolysaccharide Immune Receptor Activity Scavenger Receptor Activity Transporter Activity Protein Binding 1-phosphatidylinositol Binding High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding Identical Protein Binding High-density Lipoprotein Particle Receptor Activity
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Cell Surface Receptor Signaling Pathway Female Pregnancy Lactation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Mammary Gland Development Response To Nutrient Levels Regulation Of Multicellular Organism Growth Cellular Protein Metabolic Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Lactation	Endothelial Cell Proliferation Androgen Biosynthetic Process Cholesterol Catabolic Process Receptor-mediated Endocytosis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Storage Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Lipopolysaccharide Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Lipopolysaccharide Cholesterol Efflux High-density Lipoprotein Particle Remodeling Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Vitamin Transmembrane Transport Wound Healing Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Recognition Of Apoptotic Cell Reverse Cholesterol Transport Adhesion Of Symbiont To Host Viral Entry Into Host Cell Regulation Of Phagocytosis Intestinal Absorption Positive Regulation Of Nitric-oxide Synthase Activity Triglyceride Homeostasis Cholesterol Import
Pathways		Prolactin receptor signaling Prolactin receptor signaling Amyloid fiber formation Growth hormone receptor signaling
Drugs			Phosphatidyl serine
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Obesity ( 19151714) Paget's disease ( 21623375) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) HDL cholesterol ( 24097068 30275531 25961943 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010 31217584) LDL cholesterol levels ( 32203549) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302 20442857) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1) ( 30061609) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels (lipoprotein measures) ( 27005778) Monocyte percentage of white cells ( 32888494) Renal cell carcinoma ( 21131975) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Total bilirubin levels ( 29403010) Total cholesterol levels ( 29403010) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Vitamin E levels ( 21729881)
Interacting Genes		4 interacting genes: MEOX2 PPIB PRLR UBQLN4	9 interacting genes: APOA1 APOA2 APOE GPR35 KRTAP10-9 KRTAP5-9 LTB4R2 PDZK1 PEX5
Entrez ID		5617	949
HPRD ID		07180	03024
Ensembl ID		ENSG00000172179	ENSG00000073060
Uniprot IDs		P01236 Q5I0G2 Q5THQ0	A0A024RBS4 Q8WTV0
PDB IDs		1RW5 2Q98 3D48 3EW3 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 3NPZ
Enriched GO Terms of Interacting Partners?
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