SELENOS and SYNM

Data Source:
BioGRID (affinity chromatography technology)

		SELENOS	SYNM
Description		selenoprotein S	synemin
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex	Intermediate Filament Adherens Junction Sarcolemma Costamere Intermediate Filament Cytoskeleton Neurofilament Cytoskeleton
	Molecular Function	Protein Binding Antioxidant Activity Enzyme Binding Signaling Receptor Activity ATPase Binding Ubiquitin-specific Protease Binding	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Vinculin Binding Intermediate Filament Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Gluconeogenesis ER Overload Response Response To Glucose Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Establishment Of Protein Localization Cell Redox Homeostasis Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Inflammatory Response Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Response To Redox State Cellular Response To Lipopolysaccharide Regulation Of Nitric Oxide Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	Fast-twitch Skeletal Muscle Fiber Contraction Intermediate Filament Cytoskeleton Organization
Pathways		E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Carotid plaque burden ( 28282560) Low high density lipoprotein cholesterol levels ( 26879886)
Interacting Genes		9 interacting genes: APOA5 DERL1 GTF2IRD1 KLHDC2 KPNB1 MFHAS1 SAA1 SRPK2 VCP	5 interacting genes: DES DTNA ERBB2 ERBB3 ERBB4
Entrez ID		55829	23336
HPRD ID		12133	07305
Ensembl ID		ENSG00000131871	ENSG00000182253
Uniprot IDs		Q6GYA4 Q9BQE4	A0A075B7B1 O15061
PDB IDs		2Q2F 5KIU 5KIY 6DO4	6EWO
Enriched GO Terms of Interacting Partners?
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