LAPTM4B and TMEM67

Data Source:
BioGRID (two hybrid)

		LAPTM4B	TMEM67
Description		lysosomal protein transmembrane 4 beta	transmembrane protein 67
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Plasma Membrane Integral Component Of Membrane Late Endosome Membrane Multivesicular Body Membrane Cell Projection Multivesicular Body, Internal Vesicle	Endoplasmic Reticulum Membrane Centrosome Integral Component Of Membrane Cytoplasmic Vesicle Membrane Ciliary Transition Zone MKS Complex Ciliary Membrane
	Molecular Function	Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding Ceramide Binding Phosphatidylinositol Bisphosphate Binding	Protein Binding Filamin Binding Unfolded Protein Binding
	Biological Process	Endosome Organization Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Lysosome Organization	Negative Regulation Of Centrosome Duplication Ubiquitin-dependent ERAD Pathway Cilium Assembly Ciliary Basal Body-plasma Membrane Docking
Pathways			Anchoring of the basal body to the plasma membrane
Drugs
Diseases			Joubert syndrome COACH syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Meckel syndrome (MKS); Meckel-Gruber syndrome
GWAS		Metabolite levels ( 23823483) QT interval ( 24952745)
Interacting Genes		21 interacting genes: BDKRB1 CGRRF1 CTXN3 CYB561A3 EMP1 GJA8 GPX8 IFNAR1 IGFBP5 ISLR2 MTIF3 NAALADL2 NRG1 ODF4 PIP5K1C SCARB2 SLC22A1 SLC22A2 SLC29A2 TMEM86B TRARG1	2 interacting genes: MKS1 UBQLN1
Entrez ID		55353	91147
HPRD ID		13960	11324
Ensembl ID		ENSG00000104341	ENSG00000164953
Uniprot IDs		Q86VI4	Q5HYA8
PDB IDs
Enriched GO Terms of Interacting Partners?
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