LRRC8D and LRRC8B

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		LRRC8D	LRRC8B
Description		leucine rich repeat containing 8 VRAC subunit D	leucine rich repeat containing 8 VRAC subunit B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Membrane Ion Channel Complex	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Ion Channel Complex
	Molecular Function	Volume-sensitive Anion Channel Activity Protein Binding	Volume-sensitive Anion Channel Activity Protein Binding
	Biological Process	Inorganic Anion Transport Taurine Transport Aspartate Transmembrane Transport Transmembrane Transport Cellular Response To Osmotic Stress Anion Transmembrane Transport	Inorganic Anion Transport Transmembrane Transport Anion Transmembrane Transport
Pathways		Miscellaneous transport and binding events	Miscellaneous transport and binding events
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8	Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Cognitive function ( 25644384) Lung cancer ( 28604730) Mean platelet volume ( 32888494) Obsessive-compulsive symptoms ( 26859814) Squamous cell lung carcinoma ( 28604730) Thiopurine-induced digestive symptoms in inflammatory bowel disease ( 29923122)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494)
Interacting Genes		2 interacting genes: APP EXOSC4
Entrez ID		55144	23507
HPRD ID		11287	18145
Ensembl ID		ENSG00000171492	ENSG00000197147
Uniprot IDs		B3KRU1 Q7L1W4 Q96GG5	A0A384N5V6 Q6P9F7
PDB IDs		6M04
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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