PINX1 and ARHGEF10

Data Source:
BioGRID (biochemical)

		PINX1	ARHGEF10
Description		PIN2 (TERF1) interacting telomerase inhibitor 1	Rho guanine nucleotide exchange factor 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Kinetochore Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleoplasm Nucleolus Mitochondrion Spindle	Centrosome Cytosol
	Molecular Function	Protein Binding Telomerase Inhibitor Activity Protein-containing Complex Binding Telomerase RNA Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinesin Binding
	Biological Process	Telomere Maintenance Via Telomerase Mitotic Metaphase Plate Congression Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Protein Localization To Chromosome, Telomeric Region Protein Localization To Nucleolus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomeric DNA Binding Positive Regulation Of Protein Localization To Nucleolus	Myelination In Peripheral Nervous System Actin Cytoskeleton Organization Regulation Of Rho Protein Signal Transduction Centrosome Duplication Positive Regulation Of Stress Fiber Assembly Mitotic Spindle Assembly Activation Of GTPase Activity
Pathways			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder ( 30804558) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness ( 30510157 21909108) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (beta diversity) ( 27723756) Lymphocyte counts ( 32888494 27863252) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Monocyte count ( 32888494) Retinal vascular caliber ( 21060863) Systemic lupus erythematosus ( 26316170) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 28334899 32154731) Triglycerides ( 24097068 30275531 20686565) Type 2 diabetes ( 30054458) White blood cell count ( 32888494 27863252)	Cleft lip with or without cleft palate x maternal periconceptional alcohol use interaction (parent of origin effect) ( 31372216) Delta-6 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) End-stage renal disease ( 29885931) HOMA-B (corrected for HOMA-IR) ( 30369944) Multiple sclerosis ( 23412934) Optic disc size ( 31809533) Toenail selenium levels ( 25343990)
Interacting Genes		16 interacting genes: AIDA APP C14orf119 CACYBP EIF1AD GABPA GYS1 MCRS1 MPZ PAFAH1B2 TERF1 TERT TLK1 TNPO2 TP63 UBL5	4 interacting genes: CDC42 FHL3 RAC1 RHOA
Entrez ID		54984	9639
HPRD ID		05934	09735
Ensembl ID		ENSG00000254093	ENSG00000104728
Uniprot IDs		Q96BK5	O15013
PDB IDs
Enriched GO Terms of Interacting Partners?
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