POU4F1 and NDFIP2

Data Source:
BioGRID (genetic interference)

		POU4F1	NDFIP2
Description		POU class 4 homeobox 1	Nedd4 family interacting protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Neuron Projection RNA Polymerase II Transcription Regulator Complex	Golgi Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Integral Component Of Membrane Multivesicular Body Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Single-stranded DNA Binding Protein Binding Sequence-specific DNA Binding GTPase Binding Sequence-specific Double-stranded DNA Binding	Protein Binding WW Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Suckling Behavior Ventricular Compact Myocardium Morphogenesis Regulation Of Transcription By RNA Polymerase II Axonogenesis Synapse Assembly Mesoderm Development Heart Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration In Hindbrain Trigeminal Nerve Development Central Nervous System Neuron Differentiation Habenula Development Neuron Projection Development Positive Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Sensory System Development Peripheral Nervous System Neuron Development Regulation Of Neurogenesis Regulation Of DNA-binding Transcription Factor Activity Proprioception Involved In Equilibrioception Innervation Positive Regulation Of Cell Cycle Arrest Cellular Response To Cytokine Stimulus Cellular Response To Estradiol Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Transcription Elongation By RNA Polymerase I	Ubiquitin-dependent Protein Catabolic Process Vacuolar Transport Negative Regulation Of Gene Expression Metal Ion Transport Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Protein Transport
Pathways		Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)	Leisure-time exercise behaviour (age-stratified) ( 30102679) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Pancreatic cancer ( 20686608) Smoking status (ever vs never smokers) ( 30643258) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		4 interacting genes: ESR1 EWSR1 MAPRE3 RIT2	8 interacting genes: AQP2 ITCH LYN NEDD4 NEDD4L SMURF1 UQCRH WWP2
Entrez ID		5457	54602
HPRD ID		03379	17629
Ensembl ID		ENSG00000152192	ENSG00000102471
Uniprot IDs		Q01851	B4DGY6 Q9NV92
PDB IDs
Enriched GO Terms of Interacting Partners?
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