XRN1 and MYH10

Data Source:
BioGRID (affinity chromatography technology)

		XRN1	MYH10
Description		5'-3' exoribonuclease 1	myosin heavy chain 10
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Synapse	Stress Fiber Nucleus Cytoplasm Cytosol Polysome Cell Cortex Myosin Complex Myosin II Complex Lamellipodium Midbody Cleavage Furrow Actomyosin Extracellular Exosome Myosin II Filament
	Molecular Function	G-quadruplex RNA Binding RNA Binding 5'-3' Exoribonuclease Activity Protein Binding G-quadruplex DNA Binding Telomerase RNA Binding	Microfilament Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity RNA Stem-loop Binding ADP Binding MRNA 5'-UTR Binding Actin Filament Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Regulation Of MRNA Stability Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Puromycin	Mitotic Cytokinesis Cell Adhesion Regulation Of Cell Shape Actin Filament-based Movement Actomyosin Structure Organization Positive Regulation Of Protein Secretion Modification Of Postsynaptic Actin Cytoskeleton
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Birth weight ( 31043758) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Waist-hip ratio ( 28552196)	Type 2 diabetes ( 30130595)
Interacting Genes		66 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1 CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MIR34C MIR429 MIR7-1 MTCH2 MTREX NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36	11 interacting genes: APC BCAP31 DUX4 ECPAS MYH9 PBX1 PTEN S100A4 YWHAE YWHAG ZNF512B
Entrez ID		54464	4628
HPRD ID		10470	01178
Ensembl ID		ENSG00000114127	ENSG00000133026
Uniprot IDs		Q8IZH2	G1UI33 P35580
PDB IDs			4PD3
Enriched GO Terms of Interacting Partners?
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