PLCB2 and MTAP

  • Data Source:
  • BioGRID (proximity labelling technology)

PLCB2

MTAP

Description phospholipase C beta 2 methylthioadenosine phosphorylase
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adverse response to drug ( 30420678)
  • Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682)
  • Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444)
  • Coronary heart disease ( 21606135)
  • Cutaneous malignant melanoma ( 32341527)
  • Cutaneous nevi ( 19578365)
  • Diastolic blood pressure ( 28135244)
  • Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
  • Glycated hemoglobin levels ( 28898252)
  • Lung adenocarcinoma ( 28604730)
  • Lung cancer ( 28604730)
  • Lung cancer in never smokers ( 28604730)
  • Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011)
  • Macular thickness ( 30535121)
  • Mean spheric corpuscular volume ( 32888494)
  • Melanoma ( 21983787 28212542)
  • Nevus count ( 30429480)
  • Nevus count or cutaneous melanoma ( 32341527 30429480)
  • Pediatric bone mineral content (radius) ( 26041818)
  • Pulse pressure ( 28135244)
Interacting Genes 7 interacting genes: GNAQ MAP2K3 MAP2K6 SLC9A3R1 SNCA TRPC3 TRPM7 7 interacting genes: CDC25A CENPH EMC3 FOLH1 LYRM1 MYLIP RELB
Entrez ID 5330 4507
HPRD ID 04985 01134
Ensembl ID ENSG00000137841 ENSG00000099810
Uniprot IDs Q00722 Q59F77 Q9BVT6 A0A384ME80 Q13126
PDB IDs 2FJU 2ZKM 1CB0 1CG6 1K27 1SD1 1SD2 3LN5 3OZC 3OZD 3OZE 5EUB 5TC5 5TC6 5TC7 5TC8 6DYZ 6DZ0 6DZ2 6DZ3
Enriched GO Terms of Interacting Partners?
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