PKD1 and SOX17

Data Source:
BioGRID (affinity chromatography technology)

		PKD1	SOX17
Description		polycystin 1, transient receptor potential channel interacting	SRY-box transcription factor 17
Image
GO Annotations	Cellular Component	Golgi Membrane Polycystin Complex Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Cilium Cation Channel Complex Calcium Channel Complex Ciliary Membrane Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Wnt-activated Receptor Activity Ion Channel Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Beta-catenin Binding Transcription Factor Binding
	Biological Process	Cartilage Condensation In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Cell Cycle Arrest Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor Signaling Pathway Via JAK-STAT Heart Development Anatomical Structure Morphogenesis Wnt Signaling Pathway Peptidyl-serine Phosphorylation Spinal Cord Development Neural Tube Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Positive Regulation Of Protein Binding Response To Fluid Shear Stress Lymph Vessel Morphogenesis Cytoplasmic Sequestering Of Transcription Factor Skin Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Protein Heterotetramerization Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Cell-cell Signaling By Wnt Regulation Of G1/S Transition Of Mitotic Cell Cycle	Angiogenesis Vasculogenesis Metanephros Development Endoderm Formation Endodermal Cell Fate Specification Inner Cell Mass Cellular Morphogenesis Heart Looping Cardiogenic Plate Morphogenesis Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spermatogenesis Endodermal Cell Fate Determination Heart Development Anatomical Structure Morphogenesis Wnt Signaling Pathway Rostrocaudal Neural Tube Patterning Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Cell Growth Protein Destabilization Embryonic Heart Tube Development Cell Migration Involved In Gastrulation Positive Regulation Of Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Embryonic Foregut Morphogenesis Stem Cell Fate Specification Protein Stabilization Endocardium Formation Cardiac Cell Fate Determination Heart Formation Endocardial Cell Differentiation Common Bile Duct Development Gall Bladder Development Endodermal Digestive Tract Morphogenesis Regulation Of Stem Cell Proliferation Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Leukemia Inhibitory Factor Regulation Of Stem Cell Division Regulation Of Cardiac Cell Fate Specification
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Deactivation of the beta-catenin transactivating complex
Drugs
Diseases		Polycystic kidney disease	Vesicoureteral reflux
GWAS		Appendicular lean mass ( 33097823) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494) Major depressive disorder ( 29317602) Neutrophil count ( 32888494) Systolic blood pressure ( 30578418)	Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Factor VIII levels ( 30586737) Intracranial aneurysm ( 18997786 33199917 20364137) LDL cholesterol ( 24097068) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Pulmonary arterial hypertension ( 30527956) Total cholesterol levels ( 28334899)
Interacting Genes		30 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NCF1 NCK2 PIP5K1C PKD2 PTK2 PTPRG PXN RGS7 SIAH1 SRC TLN1 VCL VIM	1 interacting genes: CTNNB1
Entrez ID		5310	64321
HPRD ID		03203	18085
Ensembl ID		ENSG00000008710	ENSG00000164736
Uniprot IDs		P98161	Q9H6I2
PDB IDs		1B4R 6A70	2YUL 4A3N
Enriched GO Terms of Interacting Partners?
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