PEPD and BBS1

Data Source:
BioGRID (proximity labelling technology)

		PEPD	BBS1
Description		peptidase D	Bardet-Biedl syndrome 1
Image
GO Annotations	Cellular Component	Extracellular Exosome	Centrosome Cytosol Axoneme BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Manganese Ion Binding Metalloaminopeptidase Activity Proline Dipeptidase Activity	RNA Polymerase II Repressing Transcription Factor Binding Patched Binding Smoothened Binding Protein Binding
	Biological Process	Proteolysis Cellular Amino Acid Metabolic Process Collagen Catabolic Process	Visual Perception Sensory Perception Of Smell Golgi To Plasma Membrane Protein Transport Photoreceptor Cell Maintenance Response To Stimulus Cilium Assembly Protein Localization To Cilium Non-motile Cilium Assembly
Pathways			BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Adiponectin levels ( 22479202 31178129 24105470) Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Birth weight ( 27680694) Bitter alcoholic beverage consumption ( 31046077) Creatine kinase levels ( 29403010) Fasting blood insulin (BMI interaction) ( 22581228) Fusiform gyrus volume ( 31530798) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 32203549 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High light scatter reticulocyte count ( 32888494) Lead levels in blood ( 25820613) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Reticulocyte count ( 32888494) Schizophrenia ( 26198764) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549 28334899 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 30275531) Type 2 diabetes ( 30297969 32499647 22158537 30718926 28869590) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500) White blood cell count ( 32888494)	Bipolar disorder ( 21926972) Height ( 28552196)
Interacting Genes		4 interacting genes: ATXN1 SPP1 TERF1 USP7	13 interacting genes: BHMT CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 PARK7 PAX2 TSPAN7
Entrez ID		5184	582
HPRD ID		01358	01950
Ensembl ID		ENSG00000124299	ENSG00000174483
Uniprot IDs		A0A140VJR2 P12955	Q8NFJ9
PDB IDs		2IW2 2OKN 5M4G 5M4J 5M4L 5M4Q 5MBY 5MBZ 5MC0 5MC1 5MC2 5MC3 5MC4 5MC5 6H2P 6H2Q 6QSB 6QSC 6SRE 6SRF 6SRG	6XT9
Enriched GO Terms of Interacting Partners?
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