PHF20 and CEP250

Data Source:
BioGRID (affinity chromatography technology)

		PHF20	CEP250
Description		PHD finger protein 20	centrosomal protein 250
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GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleoplasm Cytosol Nuclear Membrane NSL Complex MLL1 Complex	Photoreceptor Outer Segment Photoreceptor Inner Segment Centrosome Centriole Microtubule Organizing Center Cytosol Protein-containing Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding	Protein Binding Protein C-terminus Binding Protein Kinase Binding Protein Domain Specific Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Histone Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Regulation Of Signal Transduction By P53 Class Mediator	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Protein Localization To Organelle Detection Of Light Stimulus Involved In Visual Perception Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Centrosome Non-motile Cilium Assembly
Pathways		HATs acetylate histones Regulation of TP53 Degradation Regulation of TP53 Activity through Association with Co-factors Stabilization of p53	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) General cognitive ability ( 29844566) Height ( 28552196 25282103) Mean platelet volume ( 32888494) Refractive error ( 32231278)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Brain morphology (MOSTest) ( 32665545) Height ( 25429064 18391951) Refractive error ( 32231278) Ulcerative colitis ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		2 interacting genes: H3C1 H4C1	6 interacting genes: APP ATF7IP KAT2B NEK2 PLEKHA5 YWHAG
Entrez ID		51230	11190
HPRD ID		08514	09877
Ensembl ID		ENSG00000025293	ENSG00000126001
Uniprot IDs		Q9BVI0	Q9BV73
PDB IDs		2LDM 3P8D 3Q1J 3QII 3SD4 5TAB 5TBN	6OQA
Enriched GO Terms of Interacting Partners?
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