HDGFL3 and ADAMTSL3

Data Source:
BioGRID (biochemical)

		HDGFL3	ADAMTSL3
Description		HDGF like 3	ADAMTS like 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytosol	Extracellular Matrix Intracellular Membrane-bounded Organelle
	Molecular Function	Double-stranded DNA Binding Transcription Coregulator Activity Microtubule Binding Growth Factor Activity Tubulin Binding	Metalloendopeptidase Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Microtubule Depolymerization Signal Transduction Neuron Projection Development Microtubule Polymerization	Proteolysis Extracellular Matrix Organization
Pathways			Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 28724990) Asthma ( 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005) Chronic obstructive pulmonary disease ( 30804561) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 21998595 28552196 20881960 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748 20189936) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 25673412) Lean body mass ( 28724990) Optic disc size ( 31809533) Pulse pressure ( 30224653) Schizophrenia ( 28991256 25056061 29483656 30285260) Spine bone size ( 31053729) Waist circumference ( 26785701) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 26785701 25673412 28448500)
Interacting Genes		4 interacting genes: H3C1 SMURF1 SMURF2 TERF2IP	14 interacting genes: CYSRT1 GLRX3 KRT40 KRTAP1-1 KRTAP10-3 KRTAP10-6 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP5-7 MDFI NOTCH2NLA
Entrez ID		50810	57188
HPRD ID		17096	12426
Ensembl ID		ENSG00000166503	ENSG00000156218
Uniprot IDs		A0A024R216 Q9Y3E1	P82987
PDB IDs		6IIP 6IIQ 6IIR 6IIS 6IIT
Enriched GO Terms of Interacting Partners?
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