P2RY6 and UNG

Data Source:
BioGRID (two hybrid)

		P2RY6	UNG
Description		pyrimidinergic receptor P2Y6	uracil DNA glycosylase
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	G Protein-coupled ADP Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled UDP Receptor Activity G Protein-coupled UTP Receptor Activity	Damaged DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Ribosomal Small Subunit Binding
	Biological Process	Phagocytosis G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Purine-containing Compound Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Cellular Response To Pyrimidine Ribonucleotide	DNA Repair Base-excision Repair Viral Process Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of Apoptotic Process Depyrimidination Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal
Pathways		G alpha (q) signalling events P2Y receptors
Drugs			4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid
Diseases			Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Refractive error ( 32231278)	Feeling miserable ( 29500382) Feeling worry ( 29500382) Neurociticism ( 29500382) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		15 interacting genes: HOXA1 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP5-9 KRTAP9-2 MCFD2 NBPF19 NOTCH2NLA PLSCR1	5 interacting genes: APP CAPN11 PCNA RPA2 SEZ6L2
Entrez ID		5031	7374
HPRD ID		03906	01881
Ensembl ID		ENSG00000171631	ENSG00000076248
Uniprot IDs		A0A024R5I9 Q15077	E5KTA5 E5KTA6 P13051
PDB IDs		2B6R	1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7
Enriched GO Terms of Interacting Partners?
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