NOTCH4 and NEU1

Data Source:
BioGRID (affinity chromatography technology)

		NOTCH4	NEU1
Description		notch receptor 4	neuraminidase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Specific Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding Signaling Receptor Activity	Exo-alpha-sialidase Activity Protein Binding Alpha-sialidase Activity Exo-alpha-(2->3)-sialidase Activity Exo-alpha-(2->6)-sialidase Activity Exo-alpha-(2->8)-sialidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Cell Fate Determination Morphogenesis Of A Branching Structure Epithelial To Mesenchymal Transition Endothelial Cell Morphogenesis Vasculature Development Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription Of Notch Receptor Target Hemopoiesis Cell Differentiation Mammary Gland Development MiRNA Mediated Inhibition Of Translation Wound Healing Negative Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Oligosaccharide Catabolic Process Neutrophil Degranulation
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Negative regulation of NOTCH4 signaling	Glycosphingolipid metabolism Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation
Drugs			Oseltamivir
Diseases			Sialidosis; Mucolipidosis I Galactosialidosis Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Advanced glycation end-product levels ( 26083729) Age-related macular degeneration ( 22694956) Aspartate aminotransferase levels ( 29403010) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Circulating myeloperoxidase levels (serum) ( 23620142) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Colorectal cancer ( 30529582) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Food antigen IgG levels ( 24962563) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Iron status biomarkers (iron levels) ( 28334935) Joint mobility (Beighton score) ( 27182965) Longevity ( 30294719) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lupus nephritis in systemic lupus erythematosus ( 24925725) Migraine ( 27322543) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Obesity-related traits ( 23251661) Objective response to lithium treatment in bipolar disorder ( 26503763) Prostate cancer ( 23535732) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 19571808 30285260 23894747) Squamous cell lung carcinoma ( 28604730) Systemic lupus erythematosus ( 21408207) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 24837172 28067908) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Blood protein levels ( 28240269) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 28067908)
Interacting Genes		13 interacting genes: DLL4 EGFL7 ELOC FBXW7 MAML1 MAML2 MAML3 PSEN1 PSEN2 RBPJ SMAD2 SMAD3 SMAD4	29 interacting genes: AQP6 CCR9 CD79A CERS3 CERS4 CREB3 CREB3L1 CTSA EBP EEF1A1 ERGIC3 ERRFI1 GLB1 GOLM1 GPR152 GPX8 HSD17B11 JUNB KCNA2 KCNA4 LIG4 LMNA MGST3 MUC1 SLC10A1 SLC10A6 SLC18A1 SLC39A9 TMEM14B
Entrez ID		4855	4758
HPRD ID		01290	09751
Ensembl ID		ENSG00000204301	ENSG00000204386
Uniprot IDs		A0A1U9X983 Q99466	Q5JQI0 Q99519
PDB IDs
Enriched GO Terms of Interacting Partners?
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