ATP1A3 and ABCA4

Data Source:
BioGRID (affinity chromatography technology)

		ATP1A3	ABCA4
Description		ATPase Na+/K+ transporting subunit alpha 3	ATP binding cassette subfamily A member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Integral Component Of Membrane Axon Organelle Membrane Neuronal Cell Body Membrane Neuronal Cell Body Synapse Photoreceptor Inner Segment Membrane Neuron To Neuron Synapse Extracellular Vesicle	Endoplasmic Reticulum Integral Component Of Plasma Membrane Membrane Intracellular Membrane-bounded Organelle Photoreceptor Disc Membrane
	Molecular Function	Amyloid-beta Binding P-type Sodium:potassium-exchanging ATPase Activity Protein Binding ATP Binding Metal Ion Binding Chaperone Binding Ion Antiporter Activity Involved In Regulation Of Presynaptic Membrane Potential Steroid Hormone Binding	Transporter Activity Lipid Transporter Activity ATP Binding Phospholipid Transporter Activity ATPase Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylethanolamine Flippase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Flippase Activity N-retinylidene-phosphatidylethanolamine Flippase Activity
	Biological Process	Cellular Sodium Ion Homeostasis Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Cellular Potassium Ion Homeostasis Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Regulation Of Resting Membrane Potential Cellular Response To Steroid Hormone Stimulus Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Regulation Of Cardiac Conduction Cellular Response To Amyloid-beta Neuron Projection Maintenance Potassium Ion Import Across Plasma Membrane	Retinoid Metabolic Process Phospholipid Transfer To Membrane Lipid Transport Visual Perception Phototransduction, Visible Light Phospholipid Translocation Photoreceptor Cell Maintenance Transmembrane Transport
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) The canonical retinoid cycle in rods (twilight vision) ABC-family proteins mediated transport
Drugs		Ouabain
Diseases		Primary torsion dystonia (PTD)	Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Stargardt disease (STGD); Fundus flavimaculatus Retinitis pigmentosa (RP)
GWAS		Brain morphology (MOSTest) ( 32665545) Meat-related diet ( 32066663)	D-dimer levels ( 21502573) Dialysis-related mortality ( 21546767) Nonsyndromic cleft lip with cleft palate ( 28232668) Palmitoleic acid (16:1n-7) levels ( 23362303) Refractive error ( 32231278)
Interacting Genes		2 interacting genes: ATXN1 CASP8	1 interacting genes: CNGB1
Entrez ID		478	24
HPRD ID		01666	03408
Ensembl ID		ENSG00000105409	ENSG00000198691
Uniprot IDs		P13637 Q53ES0	P78363 Q6AI28
PDB IDs
Enriched GO Terms of Interacting Partners?
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